Preparation of VYXEOS

Watch a detailed walk-through of the steps to prepare and administer VYXEOS

See below for step-by-step instructions and a downloadable PDF

VYXEOS: Preparation and Administration Instructions

Steps for preparing and administering VYXEOS1

Equilibrate the appropriate number of vials of VYXEOS to room temperature for 30 minutes

Reconstitute VYXEOS

Reconstitute each vial with 19 mL of Sterile Water for Injection using a sterile syringe

  • Carefully swirl the contents of the vial for 5 minutes while gently inverting the vial every 30 seconds
  • After reconstitution but before final dilution, each mL of VYXEOS will contain 2.2 mg of daunorubicin and 5 mg of cytarabine

Do not heat, vortex, or shake vigorously

Let reconstituted vials rest

After reconstitution, let rest for 15 minutes

  • The reconstituted product should be an opaque, purple, homogeneous dispersion, essentially free from visible particulates
Withdraw reconstituted VYXEOS

Gently invert each vial 5 times and aseptically withdraw the calculated volume of reconstituted product from the vial(s) using a sterile syringe

If the reconstituted product is not diluted into an infusion bag immediately, it can be stored at 2°C to 8°C (36°F to 46°F) for up to 4 hours
Transfer VYXEOS into IV bag

Transfer the calculated volume to an infusion bag containing 500 mL of 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP

  • Discard any unused portion or residual product remaining in the vial and do not save any unused portions for later administration

Gently invert the bag to mix the solution

  • Only solutions without visible particulates should be used
If the diluted product is not used immediately, it can be stored at 2°C to 8°C (36°F to 46°F) for up to 4 hours